Moraxella catarrhalisis only a weak activator of the mannose-binding lectin (MBL) pathway of complement activation

Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.

The complement system plays an important role in innate immunity. In the lectin complement pathway, mannose-binding lectin (MBL) and ficolins act as recognition molecules, and MBL-associated serine protease (MASP) is a key enzyme. It has been suggested that MASP-2 is responsible for the activation of C4. Other serine proteases (MASP-1 and MASP-3) are also associated with MBL or ficolins; howeve...

mannose-binding lectin mediated complement pathway in autoimmune neurological disorders

multiple sclerosis (ms) is a complex, demyelinating disease of the central nervous system (cns) with variable phenotypic presentations, while guillain-barre syndrome (gbs) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. myasthenia gravis (mg) is a t cell dependent and antibody mediated autoimmune disease. although it has been shown that complement plays...

The mannan-binding lectin (MBL) pathway of complement activation: biochemistry, biology and clinical implications.

MBL is an oligomeric protein designed to recognize pathogen-associated molecular patterns (PAMPs). It belongs to the family of collagen-like defence molecules characterized by being comprised of several subunits each composed of three polypeptides. The polypeptide of about 30 kD presents a collagen region attached to a globular head containing the recognition structure. Each subunit thus presen...

P 144: Sunflower Mannose binding Lectin-Associated Serine Protease Inhibitor-1 (SFMI-1) and -2: Significant Inhibitors of Mannose binding Lectin Pathway which Helps in Multiple Sclerosis Treatment

One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...

Bacteria despite MBL Binding Opsonophagocytosis of Yeasts but Not of Mannose-Binding Lectin (MBL) Facilitates